Education

• 2006. 7 – 2007. 10 Howard Hughes Medical Institute, Research Associate, University of Illinois, Urbana-Champaign
• 2005. 7 – 2006. 7 University of Illinois, Urbana-Champaign, Research Associate, Department of Physics
• 2004. 9 – 2005. 6 Seoul National University, Research Fellow Inter-University Semiconductor Research Center
• 2000. 3 – 2004. 8 Seoul National University, Ph.D. in Electrical Engineering Thesis advisor: Prof. Sin-Doo Lee
• 1998. 3 – 2000. 2 Seoul National University, M.S. in Electrical Engineering
• 1994. 3 – 1998. 2 Seoul National University, B.S. in Electrical Engineering

Professional Experience

• 2021.06 National grant for leading scientists, Investigator, National Research Foundation
• 2020.03 Seoul National University, Professor School of Biological Sciences
• 2020.05 Proteina CO., LTC. CEO
• 2016.03 - 2017.02 Yonsei University, Professor Yonsei-IBS Institute
• 2007.03 - 2016.02 KAIST, Associate Professor with tenure Department of Physics

Honors and Awards

• 2022 Selected as a Leading Scientist by the Korean Academy of Science and Technology
• 2022 Seoul National University Academic Research and Teaching Awards (Academic Research Discipline)
• 2020 100 Outstanding Research Achievements of 2020 funded by the Korean government
• 2019 Elected as a member of Young Korean Academy of Science and Technology
• 2017 Kyung-Ahm Prize (Life Sciences)

Research Interests

• Dr. Yoon conducts research focused on elucidating cellular organization principles for membrane proteins and developing methods to precisely control them. Specifically, he utilizes single-molecule biophysics and cell biology techniques to uncover the folding mechanisms of multi-pass membrane proteins. Recently, he has developed high-throughput analytical technologies for protein-protein interactions (PPIs) to discover PPI biomarkers capable of predicting drug responses in cancer. Furthermore, by generating massive datasets on antibody-antigen interactions, he is actively involved in building artificial intelligence models designed to engineer novel antibody therapeutics.
• He received his B.S., M.S., and Ph.D. degrees in Electrical, Electronic, and Control Engineering from Seoul National University. He subsequently held postdoctoral and faculty positions at the Inter-university Semiconductor Research Center at Seoul National University, the University of Illinois, and Korea Advanced Institute of Science and Technology (KAIST). He is currently a Professor in the School of Biological Sciences at Seoul National University. Additionally, he leads major scientific initiatives as the Director of the National Grants for Leading Scientists (supported by the Ministry of Science and ICT) and as the Principal Investigator of the Cloud AI Antibody Bank Project.

Publications (Max 5)

• S. A. Kim, H. G. Kim, W. C. Bhashini Wijesinghe, D. Min1 & T.-Y. Yoon1 / Emerging Patterns in Membrane Protein Folding Pathways / Annual Review of Biophysics 54, 141 (2025).
• C. Chun, J. M. Byun, M. Cha, H. Lee, B. Choi, H. Kim, S. Hong, Y. Lee, H. Park, Y. Koh1 & T.-Y. Yoon1 / Predicting the efficacy of BH3 mimetics through the profiling of multiple protein complexes in acute myeloid leukemia / Nature Biomedical Engineering 8, 1379 (2024)
• H.-K. Choi, H. Kang, C. Lee, H. G. Kim, B. P. Phillips, S. Park, C. Tumescheit, S. A. Kim, H. Lee, S.-H. Roh, H. Hong, M. Steinegger, W. Im, E. A. Miller1, H.-J. Choi1, & T.-Y. Yoon1 / Evolutionary balance between foldability and functionality of a glucose transporter / Nat. Chem. Biol. 18, 713-723 (2022).
• H.-K. Choi, H. G. Kim, M. J. Shon & T.-Y. Yoon / High-resolution Single-molecule Magnetic Tweezers / Annual Review of Biochemistry 91, 33-59 (2022).
• B. Choi, M. Cha, G. S. Eun, D. H. Lee, S. Lee, M. Ehsan, P. S. Chae, W. D. Heo, Y. Park & T.-Y. Yoon / Single-molecule functional anatomy of endogenous HER2-HER3 heterodimer /eLife 9, e53934 (2020).
• H.-K. Choi, D. Min, H. Kang, M. J. Shon, S.-H. Rah, H. Jeong, H.-J. Choi1, J. U. Bowie1 & T.-Y. Yoon1 / Watching helical membrane proteins fold reveals a common N- to C-terminal folding pathway /Science 366, 1150-1156 (2019).
• H.-W. Lee, B. Choi, H. N. Kang, H. Kim, A. Min, M. Cha, J. Y. Ryu, S. Park, J. Sohn, K. Shin, M. R. Yun, J. Y. Han, M. J. Shon, C. Jeong, J. Chung, S.-H. Lee, S.-A. Im1, B. C. Cho1 & T.-Y. Yoon1 /Profiling of protein-protein interactions via single-molecule techniques predicts the dependence of cancers on growth-factor receptors /Nature Biomedical Engineering 2, 239 (2018).